The present study was aimed at preparing salicylic acid microemulsion system formulated with garlic oil for topical drug carrier system for better therapeutic effect. Pseudoternary phase diagrams were used to obtain the concentration ranges of the oil (garlic oil), surfactant (tween 20 and tween 80) and co-surfactant (propylene glycol) for microemulsion formation. Four different formulations were formulated with various amount of oil (24 -35%), water (4 -10%) and mixture of surfactant and co-surfactant (60-66%). The microemulsion formulation characterized for its % transmittance, viscosity, pH, drug content, surface morphology, zeta potential, in-vitro drug release and stability evaluation. The optimized microemulsion formulation M2 showed more transmittance, drug content, pH of 6.12, less viscous and 91.91% cumulative drug release. These results indicate that the microemulsion system studied is a promising tool for the topical delivery of salicylic acid.
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